One In Ten
1 in 10 people will experience problems with their liver at some point in their life.
Help us FIGHT liver disease.
Anna Hadjihambi is Team Leader of Liver-Brain Axis research at the Roger Williams Institute of Hepatology, and Adjunct Lecturer at the School of Immunology and Microbial Sciences at King's College London.
Anna is Chair of the ISHEN Translational Committee and the ISHEN Secretary elect.
Contact Dr Hadjihambi: email@example.com
Dr Hadjihambi’s translational research focuses on dissecting the molecular mechanisms linking chronic liver disease to brain dysfunction, accelerated brain ageing and neurodegenerative conditions. The main project of the group uses state-of-the-art in vivo, molecular and imaging techniques, combined with human data analysis in order to investigate the pathological mechanisms underlying the effects of NAFLD on the cerebrovascular and brain function. The aim is to obtain knowledge that will lead to the development of novel and effective neuroprotective therapies.
Schematic diagram summarising factors, contributing to the pathogenesis of NAFLD and possibly increasing the risk of development and progression of neurodegenerative diseases.
Christos Konstantinou | Laboratory Technician
Deepika Goel | MRes Student: Biomedical and Molecular Sciences Research Masters
Matthew Siddle | Neuro-Immune Wellcome Trust PhD Programme - student on rotation
Hadjihambi A., Konstantinou C., Klohs J., Monsorno K., Guennec L. A., Donnelly C., et. al. 2022. Partial MCT1 invalidation protects against diet-induced non-alcoholic fatty liver disease and the associated brain dysfunction. J Hepatol; 78 (1): 180-190. https://doi.org/10.1016/j.jhep.2022.08.008.
Hadjihambi A. 2021. Cerebrovascular alterations in NAFLD: Is it increasing our risk of Alzheimer’s disease?. Anal Biochem, 636: 114387. https://doi.org/10.1016/j.ab.2021.114387
Hadjihambi A., Pierzchala K., Cudalbu C., Simicic D., Donnelly C., Konstantinou C., et. al. 2022. Ammonia impairs brain oxygenation in an animal model of minimal hepatic encephalopathy. J Hepatol Reports; 4 (8): 100509. https://doi.org/10.1016/j.jhepr.2022.100509
Hadjihambi, A., Karagiannis, A., Theparambil, S. M., Ackland, G. L. & Gourine, A. V. 2020. The effect of general anaesthetics on brain lactate release. Eur J Pharmacol; 881:173188. https://doi.org/10.1016/j.ejphar.2020.173188
Hadjihambi A., Harrison I. F., Costas-Rodriguez M., Vanhaecke F., Arias N., Gallego-Duran R., et al. 2018. Impaired brain glymphatic flow in experimental hepatic encephalopathy. J Hepatol;70(1):40-49. https://doi.org/10.1016/j.jhep.2018.08.021
Hadjihambi, A., De Chiara, F., Hosford, P. S., Habtetion, A., Karagianis, A., Davies, H., et al. 2017. Ammonia mediates cortical hemichannel dysfunction in rodent models of chronic liver disease. Hepatology, 65, 1306-1318. https://doi.org/10.1002/hep.29031
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