Dr Wing-kin Syn


Professional experience: 



Head of Liver Regeneration and Repair Research Group, Institute of Hepatology, London     


2010 – 2011 

Clinician-Scientist (Senior Research Fellow), University of Birmingham


2007 – 2010 

Senior Research Associate (NIH-funded), Duke University, NC, USA


2002 – 2007

Specialist Training in Gastroenterology and Hepatology, UK           


1998 – 2002

Junior Medical Training (Sheffield, Birmingham, Kings)


1993 – 1998

University of Sheffield Medical School , UK




Research Interests: My research focuses on mechanisms of liver regeneration and repair. Previously, I had shown that Hedgehog pathway activation promotes nonalcoholic fatty liver disease progression through enhancing the innate immune response, thus, coining the concept of ‘repair-associated inflammation’. Currently, my group is studying the role of the Hedgehog-regulated protein, Osteopontin in hepatic inflammation, fibrogenesis and carcinogenesis.


Honours and Awards

2012    Royal College of Physicians (London), Linacre Lecture and Medal   ; Association for National European and Mediterranean Societies of Gastroenterology, Rising Star Award and Lecture; 2011 BASL Dame Sheila Sherlock Lecture and Prize        .

2013    Sir Francis Avery Jones Award and Lecture, British Society of Gastroenterology


Publications and presentations (selected):

Syn WK, Agboola KM, Swiderska M et al. NKT associated hedgehog and osteopontin drives nonalcoholic fatty liver disease progression.  Gut  2012 Sep; 61(9):1323-9

Syn WK, Choi SS, Liaskou E et al. Osteopontin is induced by Hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis. Hepatology 2011 Jan;53(1):106-15 (IF: 10.9)

Syn WK, Oo YH, Pereira TA et al. Accumulation of natural killer T cells in progressive nonalcoholic fatty liver disease. Hepatology 2010 Jun; 51(6):1998-2007 (IF: 10.9)

Syn WK, Jung Y, Omenetti A et al. Hedgehog-mediated epithelial-to-mesenchymal transition and fibrogenic repair in non-alcoholic fatty liver disease. Gastroenterology 2009; October; 137(4): 1478-1488 (IF: 12.4)

Syn WK, Witek RP, Curbishley SM et al. Role for hedgehog pathway in regulating growth and function of invariant NKT cells. European Journal of Immunology2009; 39(7): 1879-1892. PMID: 19544307

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