Dr Shilpa Chokshi

I am Head of the Liver Immunology Research Group and Chief Scientific Officer of the  Institute of Hepatology, London. My early research interests largely focused on viral hepatitis, with special emphasis on the mechanisms of host immune control of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection and the pathogenesis of liver damage triggered by these viruses.  More recently I have expanded my areas of work to include new studies into Alcoholic Liver Disease (ALD) and susceptibilty to infection, and immuno-therapeutic targets for hepatocellular carcinoma (HCC). 

Prolonged, uncontrolled systemic inflammation is a key driver of liver injury and disease progression. Paradoxically, this hyper-activated immunity is often associated with immunoparesis with loss of effective anti-pathogen and anti-tumour immunity. My research is aimed at understanding this state to develop disease-specific host-targeted immunomodulatory strategies to rebalance this skewed equilibrium. 

More on my research:

Chronic Viral Hepatitis

Alcoholic Liver Disease (ALD) & Susceptibility to Infection

Hepatocellular Carcinoma

 

Contact Dr Shilpa Chokshi:  s.chokshi@researchinliver.org.uk

 

Research Team in the Institute of Hepatology: Dr Sandra Phillips, Dr Antonio Riva, Mrs Helen Edwards, Dr Elena Palma, Mr Sameer Mistry, Ms Nicola Harris, Ms Dhruti Devhsi

Students at the Institute of Hepatology: Dr Huyen Adams (PhD), Dr Doug Corrigall (MD), Ewald Doornebal (PhD)

Key collaborators:  Professor Nigel Heaton, Mr Krish Menon, Dr Rosa Miquel, Dr Raj Srirajaskanthan, Dr Abid Suddle (King College Hospital); Dr Marietta Simonova (MMA, Bulgaria); Professor Vicente Arroyo, Professor Jonel Trebicka (EF-CLIF); Dr Alex Evans (Royal Berkshire); Dr Gavin Wright (Basildon and Thurrock University Hospital); Dr Lindsey Edwards, Dr Vishal Patel (Foundation for Liver Research); Professor Farzin Farzaneh, Dr Mark McPhail (Kings College London); Professor Adrian Shepherd (Birkbeck College, UoL); Professor Jas Bajaj (Virginia Commonwealth University, USA); Professor Mark Thursz (Imperial College London); Professor Paul Klenerman (Oxford University); Dr Ye Oo (University of Birmingham); Professor Simon Eaton (GOSH); Dr Wen-Xing Ding (Kansas city, USA)

Key Publications:

Cooksley H, Riva A, Katzarov K, Hadzhiolova-Lebeau T, Pavlova S, Simonova M, Williams R, Chokshi S. Differential expression of immune-inhibitory checkpoint signatures on antiviral and inflammatory T-cell populations in chronic hepatitis B. Journal of Interferon and Cytokine Research. 2018 (accepted, in press).

Riva A, Patel V, Kurioka A, Jeffery HC, Wright G, Tarff S, Shawcross D, Ryan J, Evans A, Azarian S, Bajaj J, Fagan A, Patel V, Mehta K, Lopez C, Simonova M, Katzarov K, Hadzhiolova T, Pavlova S, Wendon J, Oo Y, Klenerman P, Williams R, Chokshi S. Mucosa-associated invariant T-cells link intestinal immunity with antibacterial immune defects in Alcoholic Liver Disease. Gut. 2018. (https://www.ncbi.nlm.nih.gov/pubmed/29097439)

Phillips S, Mistry S, Riva A, Cooksley H, Hadzhiolova-Lebeau T, Plavova S,Katzarov K, Simonova M, Zeuzem S, Woffendin C, Chen PJ, Peng CY, Chang TT, Lueth S, De Knegt R, Choi MS, Wedemeyer H, Dao M, Kim CW, Chu HC, Wind-Rotolo M, Williams R, Cooney E, Chokshi S. Peg-Interferon Lambda Treatment Induces Robust Innate and Adaptive Immunity in Chronic Hepatitis B Patients. Front Immunol. 2017. (https://www.ncbi.nlm.nih.gov/pubmed/28611778)

Markwick LJ, Riva A, Ryan JM, Cooksley H, Palma E, Tranah TH, Manakkat Vijay GK, Vergis N, Thursz M, Evans A, Wright G, Tarff S, O'Grady J, Williams R, Shawcross DL, Chokshi S. Blockade of PD1 and TIM3 restores innate and adaptive immunity in patients with acute alcoholic hepatitis. Gastroenterology. 2015. (https://www.ncbi.nlm.nih.gov/pubmed/25479137)

Chokshi S & Phillips S, Chatterji , Riva A, Bobardt M, Williams R, Gallay P, Naoumov NV.  Alisporivir inhibition of hepatocyte cyclophilins reduces HBV replication and hepatitis B surface antigen production. Gastroenterology. 2015. (https://www.ncbi.nlm.nih.gov/pubmed/25305505)

Riva A, Laird M, Casrouge A, Ambrozaitis A, Williams R, Naoumov NV, Albert ML Chokshi S. Truncated CXCL10 is associated with failure to achieve spontaneous clearance of acute hepatitis C infection. Hepatology. 2014. (https://www.ncbi.nlm.nih.gov/pubmed/24668726)

 

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