Dr Shilpa Chokshi

Professional experience:

2016 -

Principal Scientist and Head of Viral Hepatitis/Alcohol Group, Institute of Hepatology London; Honorary Senior Lecturer, King's College London

2010 - 2016 Head of Viral Hepatitis/Alcohol Group and Institute Scientific Manager, Institute of Hepatology; Honorary Senior Lecturer, University College London; Senior Research Fellow, Birkbeck College, University of London

2007- 2010

Lecturer in Hepatology/Institute Manager, University College London

1996-2007

Senior Scientist, University College London

1992-1997

Research Assistant, Institute of Liver Studies, King’s College Hospital, London

Research Interests: These have largely focused on viral hepatitis, with special emphasis throughout my career on the mechanisms of host immune control of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection and the pathogenesis of liver damage triggered by these viruses. Recently I have additionally been leading new studies into the mechanisms of alcohol-induced liver injury.

Publications and presentations (selected):

Phillips S, Chokshi S, Riva A, Evans A, Williams R, Naoumov NV. CD8(+) T cell control of hepatitis B virus replication: direct comparison between cytolytic and noncytolytic functions. J Immunol.2010.184(1):287-295

Evans, A., Riva A., H. Cooksley, S. Phillips, S. Puranik, A. Nathwani, S. Brett, Naoumov NV, Chokshi S 2008. Programmed death 1 expression during antiviral treatment of chronic hepatitis B: Impact of hepatitis B e-antigen seroconversion. Hepatology.2008 Sep;48(3):759-69.

Chokshi S, Cooksley H*, Maayan Y, Wedemeyer H, Andreone P, Gilson R, Warnes T, Paganin S, Zoulim F, Frederick D, Neumann A, Brosgart CL, Naoumov NV. 2008. Hepatitis B virus e antigen loss during adefovir dipivoxil therapy is associated with enhanced virus-specific CD4+ T-cell reactivity. Antimicrob. Agents Chemother. 52:312-320.

Palma E, Clemens D, Riva A, Williams R, Chokshi S. Perturbation of the mitochondrial network architecture in an in vitro model of alcohol-induced liver toxicity. Oral presentation AASLD monothematic conference. Atlanta, Georgia, USA, 2012.

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