One In Ten
1 in 10 people will experience problems with their liver at some point in their life.
Help us FIGHT liver disease.
Researching biomarkers of liver damage using metabolic profiling of urine, blood, and intact liver tissue.
The aim is to provide earlier markers of liver disease before symptoms are obvious clinically, for example the early indications of liver cancer.
Visiting Scientist,
The Francis Crick Institute, London
Contact Dr I. Jane Cox:
j.cox@researchinliver.org.uk
Twitter: @IJCox_NMR
ORCID
Scopus
Pioneers, innovators and advocates recognised with RCP honorary fellowships | RCP London
Research:
Dr Cox is particularly interested in using NMR spectroscopy techniques to provide a non-selective snapshot of a range of metabolic processes. These studies can also be used to document liver disease progression, including the impact of the microbiome in patients with cirrhosis.
Projects:
Professor Sasi Conte, Drs James Jarvis & Adrien Le Guennec, King’s College London, UK;
Drs Geoff Kelly & Alain Oregioni, The Francis Crick Institute, London, UK;
Professor Jasmohan Bajaj, Virginia Commonwealth University, USA;
Professor Ramazan Idilman, University of Ankara, Turkey;
Professor Aldo Torre, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico;
Dr Marcela Peña Rodríguez, Laboratory for the Diagnosis of Emerging and Reemerging Diseases (LaDEER), University Center for Health Sciences, University of Guadalajara, Mexico;
Professor Luca Valenti, Fondazione IRCSS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy;
Dr Mamun Al-Mahtab, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh;
Professor Rajiv Jalan & Dr Jane McNaugthan, UCL Institute for Liver and Digestive Health, London, UK;
Professor Simon D Taylor-Robinson, Emeritus, Imperial College London, UK.
Is reduced circulating FABP2 a biomarker of enterocyte functional change rather than cell death in patients with severe COVID-19? Assante G, Tourna A, Carpani R, Ferrari F, Prati D, Peyvandi F, Blasi F, Bandera A, Le Guennec A, Chokshi S, Patel VC, COX IJ*, Valenti L*, Youngson NA*. Sci Rep. 2022 Nov 5;12(1):18792. doi: 10.1038/s41598-022-23282-x.
Stool microbiota, compared to salivary microbiota, show more extensive correlations with plasma metabolites in decompensated cirrhosis in a multinational cirrhosis cohort. COX IJ, Peña Rodríguez M, Fagan A, Rojas-Lara MV, Le Guennec A, Rodriguez-Alvarez F, McGeorge S, Escalona-Nandez I, Torre A, Bajaj JS. Liver Int. Liver International. 2022;42:2274–2282. https://doi.org/10.1111/liv.15329.
Pro-arrhythmic effects of elevated branched chain amino acid levels. Portero V, Nicol T, Podliesna S, Marchal GA, Baartscheer A, Casini S, Tadros R, Treur JL, Tanck MWT, COX IJ, Probert F, Hough TA, Falcone S, Beekman L, Müller-Nurasyid M, Kastenmüller G, Gieger C, Peters A, Kääb S, Sinner MF, Blease A, Verkerk AO, Bezzina CR, Potter PK, Remme CA. Cardiovasc Res. 2022;118: 1742–1757. doi: 10.1093/cvr/cvab207.
Metabolomics and microbial composition increase insight into the impact of dietary differences in cirrhosis. COX IJ, Idilman R, Fagan A, Turan D, Ajayi L, Le Guennec A, Taylor-Robinson SD, Karakaya F, Gavis EA, Atkinson RA, Williams R, Sikaroodi M, Nizam S, Gillevet PM, Bajaj JS. Liver International 2020; 40: 416–42. Epub Sep 23 2019. doi: 10.1111/liv.14256.
Fecal microbiota transplant from a rational stool donor improves hepatic encephalopathy: A randomized clinical trial. Bajaj JS, Kassam Z, Fagan A, Gavis EA, Liu E, COX IJ, Kheradman R, Heuman D, Wang J, Gurry T, Williams R, Sikaroodi M, Fuchs M, Alm E, John B, Thacker LR, Riva A, Smith M, Taylor-Robinson SD, Gillevet P. Hepatology 2017; 66: 1727-1738. DOI: 10.1002/hep.29306. Epub 6 Jun 2017. #Top20Article Downloaded Article 2017-18.
Urinary proton NMR spectroscopy of a Bangladeshi cohort with hepatocellular carcinoma corroborates a urinary fingerprint for liver cancer. COX IJ, Aliev AE, Crossey MME, Dawood M, Al-Mahtab M, Akbar SMR, Rahman S, Williams R, Taylor-Robinson SD. World J Gastroenterol 2016; 22: 4191-4200. DOI: 10.3748/wjg.v22.i16.4191.
PhD (Chemistry, University of East Anglia, Norwich, UK);
BA Natural Sciences (Chemistry, University of Cambridge, Cambridge, UK).
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