Alcohol and the Liver
Much of the Foundation's research in this area has been aimed at developing a better understanding of the injury to the liver caused by binge drinking and other acute ‘insults’ which lead to alcoholic hepatitis and all its devastating consequences. In patients with cirrhosis there are changes in the mechanisms which monitor and control blood flow as part of the body’s blood circulation. Changes in circulation combine with blockages or restrictions in the blood flow within the liver and lead to development of portal hypertension (high blood pressure in the system of blood vessels between the liver and digestive organs). Increased pressure in the portal vein causes large veins (varices) to develop across the oesophagus and stomach to bypass the blockage. The varices become fragile and can bleed easily. Other associated problems are fluid retention and reduced renal (kidney) blood flow. Researchers are developing a simulated model of the condition which can then be used to explore the problems in blood flow that arise and the specific substances such as nitric oxide and asymmetric dimethylarginine (ADMA) that are involved or which might be used to treat the condition.
George Best was a supporter of the work of the Foundation during his life and a Fellowship has been established in his memory.
